SHIP1-Expressing Mesenchymal Stem Cells Regulate Hematopoietic Stem Cell Homeostasis and Lineage Commitment During Aging
نویسندگان
چکیده
منابع مشابه
Hematopoietic stem/progenitor cell commitment to the megakaryocyte lineage.
The classical model of hematopoiesis has long held that hematopoietic stem cells (HSCs) sit at the apex of a developmental hierarchy in which HSCs undergo long-term self-renewal while giving rise to cells of all the blood lineages. In this model, self-renewing HSCs progressively lose the capacity for self-renewal as they transit into short-term self-renewing and multipotent progenitor states, w...
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Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal relationships among all blood-cell types and has allowed their developmental mechanisms to be assayed at the single-cell level. These isolated cell populations are used to elucidate the molecular mechanism of lineage fate decision and of its plasticity directly by stage-specific enforcement or repression ...
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Advancements in human pluripotent stem cell (hPSC) research have potential to revolutionize therapeutic transplantation. It has been demonstrated that transcription factors may play key roles in regulating maintenance, expansion, and differentiation of hPSCs. In addition to its regulatory functions in hematopoiesis and blood-related disorders, the transcription factor RUNX1 is also required for...
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Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are pluripotent stem cells (PSCs), which can differentiate into nearly all types of cells and have self-renewal ability. Recent advancements in hESC and iPSC production have revolutionized their potential applications in regenerative medicine. Many patients with blood disorders can be treated or even cured with hemato...
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ژورنال
عنوان ژورنال: Stem Cells and Development
سال: 2015
ISSN: 1547-3287,1557-8534
DOI: 10.1089/scd.2014.0501